Insight to Pyroptosis in Viral Infectious Diseases

Background: Pyroptosis is defined as programmed necrosis executed by gasdermin D or E (GSDMD GSDME), which punches cellular membrane. Morphologically, pyroptosis characterized cell swelling and membrane rupture, leading to the release of contents that triggers intense inflammatory response. More more studies have found may be involved in pathogenesis viral infection, a determinant for inflammation observed most diseases. Objective: This paper aims summarize roles infectious diseases provide potential drug targets treatment diseases, will contribute medical research public health. Measures: mainly summarizes occurring caused different viruses, including human immunodeficiency virus, hepatitis enterovirus, influenza virus dengue fever virus. Meanwhile, reported mechanism underlying mediating these also described. Conclusion: Current shown double-edged sword On one hand, leads pathogenic many aggravate tissue damage initiated blocking proptosis usually relieves inflammation, exerts therapeutic effects on other moderating can defense against pathogen infection releasing immune epitopes inducing antiviral